Weber Medicine & Clinical Case Reports


March 2015, Vol. 1 (4), ISSN:2449-1624

© Author(s) 2015. This work is distributed under the Creative Commons Attribution 3.0 License.

Research Article

Protective Potential of High Molecular Weight Outer Membrane Protein of Pasteurella multocida Type 6:B

M. Ramlan 1, N. Muniandy 2, Y. No Na 3 & A. Rasedee 4

1 Veterinary Services Department Malaysia,
Wisma Tani, Block Podium 4G1, Precinth 4,
Federal Government Administration Centre, 62630 Putrajaya, Malaysia.

2 Faculty of Medicine,
Universiti Kuala Lumpur-Royal College of Medicine Perak, Ipoh,
Perak, Malaysia.

3 Veterinary Research Institute,
59 Jalan Sultan Azlan Shah, 31400 Ipoh,
Perak, Malaysia.

4  Faculty of Veterinary Medicine,
University Putra Malaysia, 43400 UPM Serdang,
Selangor, Malaysia.

 

Accepted 20th August, 2015; Available Online 27th August, 2015.


Abstract:

Iron-regulated outer membrane proteins (OMPs) of Pasteurella multocida have been shown previously to elicit superior protective immunity. We have identified that high molecular weight OMP 116 kDa was expressed when Pasteurella multocida type 6:B was grown under iron-restricted condition. The highly purified 116 kDa protein was found to be only 60% protective to mice against experimental pasteurellosis. Two other proteins with high molecular weight (MW) (87 and 71 kDa) were shown to be expressed slightly more when grown under iron-restricted condition; however, the protection afforded by 87 kDa protein was is only 40%..

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